Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors for Elderly Patients with Advanced Non-Small Cell Lung Cancer

Lung cancer is the leading cause of cancer-related mortality in both men and women and approximately 219,440 new cases of nonsmall cell lung cancer (NSCLC) were estimated to occur in the USA in 2009, which caused 159,390 NSCLC-related deaths. More than 50% of cases of advanced NSCLC are diagnosed in patients older than age 65, and recent Surveillance Epidemiology and End Results (SEERs) data suggest that the median age at diagnosis is 70 years. Until recently, the disease has been undertreated in this patient population, with a perception among many clinicians that elderly patients do not tolerate chemotherapy or radiotherapy. So, single agent chemotherapy is the recommended approach by the ASCO and International Expert Panels in unselected patients. The introduction of novel targeted therapies, such as Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitors (TKIs) which improved survival versus placebo in patients who had previously failed on chemotherapy, gives clinicians new, effective, and better tolerated options to consider when treating NSCLC in elderly patients. This paper describes the advances of EGFR TKIs for elderly patients with advanced NSCLC

Tsunami hazard for the city of Catania, eastern Sicily, Italy, assessed by means of Worst-case Credible Tsunami Scenario Analysis (WCTSA)

Eastern Sicily is one of the coastal areas most exposed to earthquakes and tsunamis in Italy. The city of Catania that developed between the eastern base of Etna volcano and the Ionian Sea is, together with the neighbour coastal belt, under the strong menace of tsunamis. This paper addresses the estimation of the tsunami hazard for the city of Catania by using the technique of the Worst-case Credible Tsunami Scenario Analysis (WCTSA) and is focused on a target area including the Catania harbour and the beach called La Plaia where many human activities develop and many important structures are present. The aim of the work is to provide a detailed tsunami hazard analysis, firstly by building scenarios that are proposed on the basis of tectonic considerations and of the largest historical events that hit the city in the past, and then by combining all the information deriving from single scenarios into a unique aggregated scenario that can be viewed as the <i>worst virtual scenario</i>. Scenarios have been calculated by means of numerical simulations on computational grids of different resolutions, passing from 3 km on a regional scale to 40 m in the target area. La Plaia beach results to be the area most exposed to tsunami inundation, with inland penetration up to hundreds of meters. The harbour turns out to be more exposed to tsunami waves with low frequencies: in particular, it is found that the major contribution to the hazard in the harbour is due to a tsunami from a remote source, which propagates with much longer periods than tsunamis from local sources. This work has been performed in the framework of the EU-funded project SCHEMA

Tsunami hazard for the city of Catania, eastern Sicily, Italy, assessed by means of Worst-case Credible Tsunami Scenario Analysis (WCTSA)

Abstract. Eastern Sicily is one of the coastal areas most exposed to earthquakes and tsunamis in Italy. The city of Catania that developed between the eastern base of Etna volcano and the Ionian Sea is, together with the neighbour coastal belt, under the strong menace of tsunamis. This paper addresses the estimation of the tsunami hazard for the city of Catania by using the technique of the Worst-case Credible Tsunami Scenario Analysis (WCTSA) and is focused on a target area including the Catania harbour and the beach called La Plaia where many human activities develop and many important structures are present. The aim of the work is to provide a detailed tsunami hazard analysis, firstly by building scenarios that are proposed on the basis of tectonic considerations and of the largest historical events that hit the city in the past, and then by combining all the information deriving from single scenarios into a unique aggregated scenario that can be viewed as the worst virtual scenario. Scenarios have been calculated by means of numerical simulations on computational grids of different resolutions, passing from 3 km on a regional scale to 40 m in the target area. La Plaia beach results to be the area most exposed to tsunami inundation, with inland penetration up to hundreds of meters. The harbour turns out to be more exposed to tsunami waves with low frequencies: in particular, it is found that the major contribution to the hazard in the harbour is due to a tsunami from a remote source, which propagates with much longer periods than tsunamis from local sources. This work has been performed in the framework of the EU-funded project SCHEMA

The effect of age on daily positive emotions and work behaviors

This study draws on socioemotional selectivity and person–job fit theories to investigate the emotional bases for age-related differences in daily task crafting and in-role performance. We tested a mediation model in which age is related to positive emotions that in turn predict task crafting and in-role performance. A total of 256 people working in multiple organizations participated in a 5-day diary study. Multilevel modeling showed that, at the person level of analysis, age is significantly and positively related to positive emotions and task crafting and, via crafting, to in-role performance. No significant mediation of high- and low-arousal positive emotions was found between age and task crafting. However, at the day level of analysis, high-arousal positive emotions are positively related to task crafting, and this in turn is positively related to in-role performance. These findings make important theoretical contributions to understanding within-person processes associated with employee age in addition to more traditional between-person factors. They also have implications for managing an age-diverse workforce by means of job crafting.info:eu-repo/semantics/acceptedVersio

Effect of n-methylacetamide concentration and thawing rate on chicken sperm quality after cryopreservation

In seeking alternative cryoprotectants to glycerol for a reference chicken semen freezing procedure, the aim of the present study was to compare the effect of two concentrations of N-Methylacetamide (MA) and two thawing rates on the quality of frozen-thawed semen. Semen samples were diluted in Lake pre-freezing extender, including 0.1 M trehalose in presence of 6% or 9% MA, loaded into straws, frozen in nitrogen vapors, and stored in liquid nitrogen. The following thawing treatments were used: 5 \ub0C for 100 s and 38 \ub0C for 30 s. Sperm quality (cell membrane integrity, motility and kinetic parameters) was assessed before and after cryopreservation. The decrease of MA concentration from 9 to 6% improved sperm quality after freezing/thawing and this effect was dependent on thawing temperature. Decreasing the MA concentration from 9 to 6% improved the proportion of undamaged membrane, motile, and progressive motile sperm recovered after thawing at 5 \ub0C for 100 s; in contrast, no effect of the MA concentration was observed thawing at 38 \ub0C for 30 s. Therefore, the treatment with 6% MA and thawing at 5 \ub0C for 100 s has given the best cryoprotective action. These results contribute to improve the efficacy of the current chicken semen cryopreservation procedures

Tsunamis From Submarine Collapses Along the Eastern Slope of the Gela Basin (Strait of Sicily)

Geophysical surveys in the eastern slope of the Gela Basin (Strait of Sicily, central Mediterranean) contributed to the identification of several episodes of sediment mass transport, recorded by scars and deposits of various dimensions within the Pleistocene succession. In addition to a huge failure called Gela Slide with volume exceeding 600 km3, the most studied events show volumes estimated between 0.5 and 1.5 km3, which is common to many other submarine landslide deposits in this region and that can therefore be considered as a characteristic value. In this work, the tsunamigenic potential of two of such landslides, the so-called Northern Twin Slide and South Gela Basin Slide located about 50 km apart along the eastern slope of the Gela Basin, are investigated using numerical codes that describe the onset and motion of the slide, as well as the ensuing tsunami generation and propagation. The results provide the wave height of these tsunami events on the coast of southern Sicily and Malta and can be taken as representative of the tsunamigenic potential of typical landslides occurring along the slope of the Gela Basin

Semen quality of Italian local pig breeds

From 1996 to 1999 a conservation programme was carried out within the framework of EC contract "European gene banking project for the pig genetic resources" (Ollivier et al., 2001) in the Italian local pig breeds. The aims of the program included the primary characterization of the breeds, i.e. information on the organization in charge of the breed, breeding population numbers, breed description and qualifications, and field trials on productive and reproductive performances. In this context the "Semen Bank of Italian local pig breeds" was built. A total of 30,835 straws of four Italian local pig breeds (Cinta Senese, Casertana, Mora Romagnola and Nero Siciliano), collected from 42 sires, have been stored. In this work semen quality traits, lipid composition and freezability of the four Italian local pig breeds are reported

Primary tumor sidedness and benefit from FOLFOXIRI plus bevacizumab as initial therapy for metastatic colorectal cancer. Retrospective analysis of the TRIBE trial by GONO

Right-sided metastatic colorectal cancer (mCRC) patients have poor prognosis and achieve limited benefit from first-line doublets plus a targeted agent. In this unplanned analysis of the TRIBE study, we investigated the prognostic and predictive impact of primary tumor sidedness in mCRC patients and the differential impact of the intensification of the chemotherapy in subgroups defined according to both primary tumor sidedness and RAS and BRAF mutational status